平安! 发表于 2011-11-9 19:57 " i; y( {# ~+ i3 |
Pazopanib (100 mg/kg/day free base equivalent)
7 L3 y; d& b; q# P4 s 这是个已经在美国上市的老药了,能下载到正式药物使用说明书英文版。7 r6 ~6 ~: e; g
搜索了一下,原料一大堆。$ A. F; g1 {! N
3 j8 S/ w" t, z) k7 W对不起!100mg/kg是用于移植瘤的,我弄错了。
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# T# g8 L0 B: @! a, P1 E' r) U- I$ k以下是正版说明书的推荐用量。4 B, l) P) W0 }! S3 I6 \" k
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--------------------- DOSAGE AND ADMINISTRATION ----------------/ s3 E' \4 T9 g) O; F
* 800 mg orally once daily without food (at least 1 hour before or 2 hours after a meal). (2.1) ! M t% V+ t$ W" h& I
* Baseline moderate hepatic impairment – 200 mg orally once daily. Not recommended in patients with severe hepatic impairment. (2.2) " @( G; H/ x$ m2 k& S. I: L! j
---------------------DOSAGE FORMS AND STRENGTHS --------------
5 _) ~! P M% t+ a200 mg tablets. (3) 1 |8 |7 I+ P6 _+ S! f# q% z+ i! F
-------------------------------CONTRAINDICATIONS------------------------ |