认领了认领了
AZD9291 First Time In Patients Ascending Dose Study
AZD9291首次在病患中逐渐增量使用的研究
http://clinicaltrials.gov/show/NCT01802632
Drug: AZD9291
Starting dose 20 mg, administered once daily.
初始剂量20MG每天
If tolerated subsequent cohorts will test increasing doses of AZD9291, until a maximum tolerated dose or maximum feasible dose is defined
耐受结果组群将试验增加AZD9291的剂量，直到得出最大可耐受剂量或最大可行剂量。
D. Ross Camidge, MD, PhD, Director, Thoracic Oncology Clinical Program, University of Colorado Cancer Center, discusses a phase I study looking at AZD9291 in patients with non-small cell lung cancer.（略，第一阶段临床试验用于非小细胞肺癌患者）
AZD9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) activating and resistance mutations and seemed to be well tolerated in the trial.
AZD9291是一种作用于EGFR的不可逆抑制剂并防止其突变，而且AZD9291似乎在试验中耐受性表现良好。
Camidge says he found it interesting that some patients did have a little bit of rash, possibly indicating that researchers are already approaching the ideal dose.
CAMIDGE说，他发现一些病人只是略有皮疹，这一现象是有趣的，可能也意味着研究者已经接近理想的剂量。
AZD9291 demonstrated about a 46% response rate overall and about a 56% response rate in T790M+ patients.
试验显示AZD9291的总体有效率为46%，T790M阳性的有效率56%。
Right now, Camidge says, AZD9291 could be a "game-changer," and anticipates a fast-track approval.
CAMIDGE说，AZD9291可能成为一项（治疗上）的颠覆者，并且参与申请快速通道的认证。
第二篇稍后翻，大致看了下，将AZD9291和CO 1686作比较。网上也查了一点，Clvs公司临床一期CO-1686效果反应很好，股价一天翻倍。
是用来对付易瑞沙耐药的吗期待！
每天必来看一下，每个新药都是患者的福音。---------------总有一款适合您
学习并期待，谢谢老马和υīСКī ！
并防止其突变,这句好亮！
福音！期待中！
不错 第一次听说 期望
顶一个，期待老马大哥进一步的好消息……